PTHR11453

ANION EXCHANGE PROTEIN

PANTHER entry
Member databasePANTHER
PANTHER typefamily

Description
Imported from IPR003020

Bicarbonate (HCO3-) transport mechanisms are the principal regulators of pH in animal cells. Such transport also plays a vital role in acid-base movements in the stomach, pancreas, intestine, kidney, reproductive organs and the central nervous system. Functional studies have suggested four different HCO3-transport modes. Anion exchanger proteins exchange HCO3-for Cl-in a reversible, electroneutral manner
[1]
. Na+/HCO3-co-transport proteins mediate the coupled movement of Na+and HCO3-across plasma membranes, often in an electrogenic manner
[3]
. Na+driven Cl-/HCO3-exchange and K+/HCO3-exchange activities have also been detected in certain cell types, although the molecular identities of the proteins responsible remain to be determined.

Sequence analysis of the two families of HCO3-transporters that have been cloned to date (the anion exchangers and Na+/HCO3-co-transporters) reveals that they are homologous. This is not entirely unexpected, given that they both transport HCO3-and are inhibited by a class of pharmacological agents called disulphonic stilbenes
[2]
. They share around ~25-30% sequence identity, which is distributed along their entire sequence length, and have similar predicted membrane topologies, suggesting they have ~10 transmembrane (TM) domains.

References
Imported from IPR003020

1.Molecular biology of the anion exchanger gene family. Kopito RR. Int. Rev. Cytol. 123, 177-99, (1990). PMID: 2289848

2.Cloning and functional expression of a human kidney Na+:HCO3- cotransporter. Burnham CE, Amlal H, Wang Z, Shull GE, Soleimani M. J. Biol. Chem. 272, 19111-4, (1997). View articlePMID: 9235899

3.The electrogenic Na/HCO3 cotransporter. Boron WF, Fong P, Hediger MA, Boulpaep EL, Romero MF. Wien. Klin. Wochenschr. 109, 445-56, (1997). PMID: 9261985

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