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Member database | PANTHER |
PANTHER type | family |
Short name | Peroxidase/ROS_Generation AI |
Description
AI-generatedUnreviewed
This family of proteins includes enzymes with peroxidase activity, which are involved in various biological processes such as thyroid hormone biosynthesis, cuticle biogenesis, immune defense, and extracellular matrix formation. Members of this family catalyze the oxidation of halides or pseudohalides in the presence of hydrogen peroxide to produce antimicrobial compounds. They play roles in the formation of sulfilimine cross-links in collagen, contributing to tissue integrity and development. Some are involved in the innate immune response, generating reactive oxygen species to limit microbial proliferation. Others participate in chorion hardening or eggshell formation by catalyzing protein cross-linking. The family also includes dual oxidases involved in reactive oxygen species production for cuticle formation and maintenance.
External Links
Representative structure
5fiw: CRYSTAL STRUCTURE OF HUMAN MYELOPEROXIDASE AT 1.7 ANGSTROMS RESOLUTION