PTHR11559

Type-B Carboxylesterase/Lipase
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameType-B_Carboxylest/Lipase
AI

Description

AI-generatedUnreviewed
The Type-B Carboxylesterase/Lipase family encompasses enzymes involved in diverse biological processes including the detoxification of xenobiotics, activation of ester and amide prodrugs, metabolism of lipids, and hydrolysis of various ester substrates. Members of this family exhibit hydrolytic activity towards compounds such as palmitoylcarnitine, retinyl esters, xenobiotics, and pyrethroid pesticides. Some are implicated in the biosynthesis of mycotoxins like patulin, while others participate in the degradation of fumonisin B1 or play roles in cell adhesion, virulence, and reproductive biology. The family's broad substrate specificity reflects its involvement in lipid metabolism, with some members preferentially acting on short-chain fatty acid esters, while others target long-chain fatty acid esters or triglycerides. The family's functional diversity is further exemplified by its role in the synthesis of fatty acid ethyl esters and involvement in reverse cholesterol transport. Collectively, the Type-B Carboxylesterase/Lipase family plays a crucial role in various physiological and biochemical pathways across different species.
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