This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member database | PANTHER |
PANTHER type | family |
Short name | PurK/PurT AI |
Description
AI-generatedUnreviewed
The PurK/PurT family includes enzymes that catalyze the ATP-dependent carboxylation of 5-aminoimidazole ribonucleotide (AIR) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) using bicarbonate as a substrate. This reaction is a critical step in the de novo biosynthesis of purine nucleotides, which are essential building blocks for DNA and RNA, as well as for the regulation of energy within cells. Members of the PurK/PurT family are found across various bacterial species, reflecting the fundamental nature of purine biosynthesis in cellular metabolism and genetic information processing.
External Links
Representative structure
3q2o: Crystal Structure of purK: N5-carboxyaminoimidazole ribonucleotide synthetase