PTHR11753

ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY

PANTHER entry
Member databasePANTHER
PANTHER typefamily

Description
Imported from IPR016635

The adaptor protein complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules
[1]
. Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3). Subunits of clathrin-associated adaptor protein complex 1 play a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or in endosomes.

This group represents an adaptor protein complex, sigma subunit.

References
Imported from IPR016635

1.The clathrin adaptor complexes as a paradigm for membrane-associated allostery. Canagarajah BJ, Ren X, Bonifacino JS, Hurley JH. Protein Sci 22, 517-29, (2013). PMID: 23424177

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