This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member database | PANTHER |
PANTHER type | family |
Short name | Serum_paraoxonase/arylesterase AI |
Description
AI-generatedUnreviewed
The paraoxonase family proteins are involved in the hydrolysis of a variety of substrates, including organophosphate insecticide metabolites, lactones, and aromatic carboxylic acid esters. Members of the family exhibit a broad spectrum of enzymatic activities, such as protecting low density lipoproteins (LDL) from oxidative modification, which is implicated in atheroma formation. Some family members are associated with high density lipoprotein and exhibit antioxidant activity, potentially preventing LDL lipid peroxidation. Additionally, certain paraoxonase family proteins are involved in mechanosensory transduction, contributing to touch sensitivity by forming part of a sodium and potassium permeable channel complex. The family's diverse functions reflect its role in enzymatic detoxification, cardiovascular protection, and sensory processes.
Integrated to
External Links
Representative structure
3sre: Serum paraoxonase-1 by directed evolution at pH 6.5