PTHR11820

Fumarylacetoacetate Hydrolase
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameFAH
AI

Description

AI-generatedUnreviewed
The FAH family is characterized by a range of enzymatic activities, primarily associated with hydrolase function. Members of the family are involved in the catabolism of various substrates, including acetylpyruvate, fumarylpyruvate, and gentisate, as well as in the recycling of oxyluciferin in the fungal bioluminescence cycle. These enzymes catalyze hydrolytic cleavage reactions that result in the formation of smaller organic compounds, such as fumarate, pyruvate, and caffeic acid. Some family members also exhibit isomerase and decarboxylase activities, converting specific substrates to different isomeric or decarboxylated forms. The FAH family includes mitochondrial acylpyruvases, which have been shown to bind copper in vitro, and enzymes involved in the degradation of aromatic compounds. The family's name reflects its association with fumarylacetoacetate hydrolase, a key enzyme in tyrosine catabolism, although the range of functions extends beyond this specific activity.
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