This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member database | PANTHER |
PANTHER type | family |
Short name | TALE_homeobox AI |
Description
AI-generatedUnreviewed
The TALE homeobox family is characterized by a conserved DNA-binding homeodomain, playing pivotal roles in developmental processes across diverse organisms. Members of this family function as transcription factors, regulating gene expression patterns critical for morphogenesis, organ development, and cellular differentiation. They are involved in meristem maintenance, leaf and shoot formation, floral development, and embryogenesis. Some proteins within this family bind specific DNA sequences, such as 5'-TGAC-3', to modulate transcriptional activities. They also form heterodimeric complexes with other homeobox proteins, enhancing DNA-binding specificity and transcriptional regulation. The TALE homeobox proteins are further implicated in hematopoiesis, vascular patterning, and neural development, with some acting as transcriptional activators or repressors in response to retinoid signaling. The family includes several subfamilies like KNOX, MEIS, PBX, and TGIF, each with distinct but overlapping functions contributing to their versatile roles in development and differentiation.
Integrated to
External Links
Representative structure
8vts: Meis1 homeobox domain bound to paromomycin fragment