PTHR11903

Oxylipin biosynthesis and metabolism
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameOxylipin_biosynth_metab
AI

Description

AI-generatedUnreviewed
The protein family is involved in the biosynthesis and metabolism of oxylipins, which are signaling molecules derived from polyunsaturated fatty acids. Members of the family exhibit dual cyclooxygenase and peroxidase activities, catalyzing the conversion of arachidonic acid to prostaglandin G2 and subsequently to prostaglandin H2, precursors to various prostanoids involved in inflammatory responses. Some members also produce hydroxyoctadecadienoates from linoleic acid and contribute to the generation of specialized pro-resolving mediators during inflammation. Additionally, the family includes enzymes that catalyze the primary oxygenation of fatty acids into hydroperoxides, playing roles in cell signaling, wound healing, and protection from infection. The family's activity is regulated by nonsteroidal anti-inflammatory drugs and other inhibitors, indicating its significance in both physiological and pathological processes.
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