This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member database | PANTHER |
PANTHER type | family |
Short name | Amidophos_ribosyltransf AI |
Description
AI-generatedUnreviewed
The Amidophosphoribosyltransferase family is involved in the first committed step of 'de novo' purine biosynthesis. Members of this family catalyze the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. This reaction is a key regulatory point in the purine biosynthesis pathway. The activity of these enzymes is typically subject to allosteric regulation and is inhibited by the end products of the pathway, such as purine nucleotides. Some family members can also use ammonia in place of glutamine for the reaction. The family is essential for cellular metabolism, as purine nucleotides are required for DNA and RNA synthesis, energy transfer, and signal transduction.
External Links
Representative structure
6czf: The structure of E. coli PurF in complex with ppGpp-Mg