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Member database | PANTHER |
PANTHER type | family |
Short name | PNGase AI |
Description
AI-generatedUnreviewed
The PNGase family proteins are involved in the deglycosylation of denatured N-linked glycoproteins within the cytoplasm, aiding in their proteasome-mediated degradation. They cleave the beta-aspartyl-glucosamine of the glycan and the amide side chain of asparagine, converting it to aspartic acid. These proteins prefer substrates with high-mannose over complex type oligosaccharides and target misfolded glycoproteins exported from the endoplasmic reticulum to the cytosol. Deglycosylation by the PNGase family is essential for the degradation of certain misfolded glycoproteins, although not all require this process. Some family members also exhibit oxidoreductase activity and play roles in regulating proteasomal subunit expression.
Integrated to
External Links
Representative structure
7zgm: Plant N-glycan specific alpha-1,3-mannosidase