PTHR12143

Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short namePNGase
AI

Description

AI-generatedUnreviewed
The PNGase family proteins are involved in the deglycosylation of denatured N-linked glycoproteins within the cytoplasm, aiding in their proteasome-mediated degradation. They cleave the beta-aspartyl-glucosamine of the glycan and the amide side chain of asparagine, converting it to aspartic acid. These proteins prefer substrates with high-mannose over complex type oligosaccharides and target misfolded glycoproteins exported from the endoplasmic reticulum to the cytosol. Deglycosylation by the PNGase family is essential for the degradation of certain misfolded glycoproteins, although not all require this process. Some family members also exhibit oxidoreductase activity and play roles in regulating proteasomal subunit expression.
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