PTHR12348

TSC-22/Dip/Bun domain-containing protein
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameTSC-22/Dip/Bun
AI

Description

AI-generatedUnreviewed
This family of proteins is involved in various cellular processes including the regulation of apoptosis, inflammation, and myogenic differentiation. Members of this family are known to protect T-cells from apoptosis induced by IL2 deprivation by inhibiting the transcriptional activity of FOXO3A, which results in the down-regulation of the pro-apoptotic factor BCL2L11. They also play a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10 in macrophages. Additionally, they can inhibit the nuclear translocation of NFKB1 in T-cells, affecting NFKB1 DNA-binding activities. In vitro, they have been shown to suppress the DNA-binding activities of the AP-1 transcription factor complex. Furthermore, they are involved in the inhibition of myogenic differentiation by regulating the transcriptional activity of MYOD1 and HDAC1, leading to reduced expression of MYOG. A characteristic structural feature of these proteins is the presence of a leucine-zipper domain, which is implicated in homodimerization.
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.