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Member database | PANTHER |
PANTHER type | family |
Short name | TSC-22/Dip/Bun AI |
Description
AI-generatedUnreviewed
This family of proteins is involved in various cellular processes including the regulation of apoptosis, inflammation, and myogenic differentiation. Members of this family are known to protect T-cells from apoptosis induced by IL2 deprivation by inhibiting the transcriptional activity of FOXO3A, which results in the down-regulation of the pro-apoptotic factor BCL2L11. They also play a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10 in macrophages. Additionally, they can inhibit the nuclear translocation of NFKB1 in T-cells, affecting NFKB1 DNA-binding activities. In vitro, they have been shown to suppress the DNA-binding activities of the AP-1 transcription factor complex. Furthermore, they are involved in the inhibition of myogenic differentiation by regulating the transcriptional activity of MYOD1 and HDAC1, leading to reduced expression of MYOG. A characteristic structural feature of these proteins is the presence of a leucine-zipper domain, which is implicated in homodimerization.