PTHR12400

INOSITOL POLYPHOSPHATE KINASE

PANTHER entry
Member databasePANTHER
PANTHER typefamily

Description
Imported from IPR005522

Inositol phosphates (IPs) act as signalling messengers to regulate various cellular processes such as growth. This entry includes a group of inositol polyphosphate kinase, including inositol polyphosphate multikinase Arg82 and Inositol hexakisphosphate/inositol heptakisphosphate kinase Kcs1 from budding yeast. They play important roles in vacuole biogenesis and the cell's response to certain environmental stresses. The kinase activity of Arg82 and Kcs1 is required for the production of soluble inositol phosphates
[6]
. Independently of its catalytic activity, Arg82 is crucial for assembling the Arg80-Mcm1 protein complex at the promoter region of genes involved in arginine metabolism
[6]
.

This entry also includes human inositol hexakisphosphate kinase 1/2/3 (IP6K1/2/3)
[5]
, inositol polyphosphate multikinase (IPMK)
[2]
and inositol-trisphosphate 3-kinase A/B/C (IP3KA/B/C)
[4]
. They are involved in inositol phosphate biosynthesis
[3]
. Independently of its catalytic activity, IPMK mediates the activation of mammalian target of rapamycin (mTOR) in response to essential amino acids
[cite:PUB00087187]
. Crystallographic analysis showed that the disordered domains of IPMK modulates its kinase activity
[1]
.

References
Imported from IPR005522

1.Crystallographic and kinetic analyses of human IPMK reveal disordered domains modulate ATP binding and kinase activity. Seacrist CD, Blind RD. Sci Rep 8, 16672, (2018). PMID: 30420721

2.The human homolog of the rat inositol phosphate multikinase is an inositol 1,3,4,6-tetrakisphosphate 5-kinase. Chang SC, Miller AL, Feng Y, Wente SR, Majerus PW. J. Biol. Chem. 277, 43836-43, (2002). View articlePMID: 12223481

3.Inositol polyphosphate multikinase signaling in the regulation of metabolism. Lee JY, Kim YR, Park J, Kim S. Ann. N. Y. Acad. Sci. 1271, 68-74, (2012). View articlePMID: 23050966

4.Ins(1,4,5)P3 3-kinase-A overexpression induces cytoskeletal reorganization via a kinase-independent mechanism. Windhorst S, Blechner C, Lin HY, Elling C, Nalaskowski M, Kirchberger T, Guse AH, Mayr GW. Biochem. J. 414, 407-17, (2008). View articlePMID: 18498254

5.Identification and characterization of a novel inositol hexakisphosphate kinase. Saiardi A, Nagata E, Luo HR, Snowman AM, Snyder SH. J. Biol. Chem. 276, 39179-85, (2001). View articlePMID: 11502751

6.Arg82p is a bifunctional protein whose inositol polyphosphate kinase activity is essential for nitrogen and PHO gene expression but not for Mcm1p chaperoning in yeast. El Alami M, Messenguy F, Scherens B, Dubois E. Mol. Microbiol. 49, 457-68, (2003). View articlePMID: 12828642

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.