PTHR12537

Pumilio RNA-binding
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short namePumilio_RNA-bd
AI

Description

AI-generatedUnreviewed
The Pumilio homolog family comprises RNA-binding proteins that regulate gene expression post-transcriptionally. Members of this family bind to specific sequences in the 3'-UTR of target mRNAs, controlling their translation and stability. The family is characterized by the presence of pumilio repeats, which form a right-handed superhelix structure that mediates RNA association. This structure binds RNA on its concave side, with each repeat recognizing a single nucleotide. Specificity for RNA bases is achieved through base-specific interactions involving key residues within the repeats. The family plays diverse roles, including repressing mRNA targets to maintain genomic stability, regulating stem cell proliferation and differentiation, facilitating miRNA regulation, and participating in cytoplasmic viral infection responses. Some members also localize mRNAs encoding mitochondrial proteins for translation near mitochondria, influencing mitochondrial biogenesis and function.
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