This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member database | PANTHER |
PANTHER type | family |
Short name | Ku_NHEJ_telomere_maint AI |
Description
AI-generatedUnreviewed
The Ku protein family is involved in the DNA non-homologous end joining (NHEJ) pathway, essential for double-strand break repair. Members of the family function as single-stranded DNA-dependent ATP-dependent helicases. They exhibit sequence-independent DNA-binding with high affinity to nicks and ends of duplex DNA, providing chromosomal end protection. The family plays a crucial role in telomere maintenance, interacting with telomeric repeats and subtelomeric sequences to control telomere length and protect against rearrangement. Additionally, they maintain telomeric chromatin for gene silencing at telomeres. The heterodimer formed by Ku70 and Ku80 subunits is involved in the recruitment of telomerase and other factors for telomere elongation and recombination. This family also participates in processes such as V(D)J recombination, chromosome stability, and transcription regulation. Some members have been implicated in the innate immune response through the cGAS-STING pathway.
External Links
Representative structure
6tyu: Structure of Ku80 von Willebrand domain complexed with MRI Ku Binding Motif