This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member database | PANTHER |
PANTHER type | family |
Short name | Deoxyhypusine_hydroxylase AI |
Description
AI-generatedUnreviewed
The deoxyhypusine hydroxylase family is responsible for the post-translational modification of eukaryotic translation initiation factor 5A (eIF-5A) through the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine. This unique amino acid residue, hypusine, is essential for the function of mature eIF-5A. The modification is a two-step process where deoxyhypusine synthase (DHPS) first synthesizes the intermediate, which is then hydroxylated by deoxyhypusine hydroxylase. Hypusination is critical for various cellular processes including cell growth, proliferation, autophagy, and protein synthesis. The family's activity is also known to be inhibited by certain metal chelators, which can affect organismal growth.
External Links
Representative structure
4d4z: STRUCTURE OF HUMAN DEOXYHYPUSINE HYDROXYLASE in complex with glycerol