PTHR13232

NAD(P)H-HYDRATE EPIMERASE

PANTHER entry
Member databasePANTHER
PANTHER typefamily

Description
Imported from IPR032976

This entry represents a subgroup of the YjeF N-terminal domain-containing proteins from eukaryotes, bacteria and archaea, including NAXE and YJEFN3 from humans
[4]
. NAXE is an NAD(P)H-hydrate epimerase that has been shown to regulate cholesterol efflux from endothelial cells
[3]
. YJEFN3 may play a role in spermiogenesis and oogenesis
[2]
.

In bacteria or archaea, YjeF N-terminal domains are often fused to a YjeF C-terminal domain
[1]
. It is a bifunctional enzyme that catalyses the epimerisation of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP
[1]
. However, this entry represents the subgroup that only contain the YjeF N-terminal domain.

The reduced forms of NAD and NADP, two major nucleotides playing a central role in metabolism, are continuously damaged by enzymatic or heat-dependent hydration. Eukaryotic NAD(P)H-hydrate epimerase catalyses the epimerisation of the S- and R-forms of NAD(P)HX, the damaged form of NAD(P)H. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX
[1]
.

References
Imported from IPR032976

1.Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair. Marbaix AY, Noel G, Detroux AM, Vertommen D, Van Schaftingen E, Linster CL. J. Biol. Chem. 286, 41246-52, (2011). View articlePMID: 21994945

2.ApoA-I-binding protein (AI-BP) and its homologues hYjeF_N2 and hYjeF_N3 comprise the YjeF_N domain protein family in humans with a role in spermiogenesis and oogenesis. Rudolph C, Sigruener A, Hartmann A, Orso E, Bals-Pratsch M, Gronwald W, Seifert B, Kalbitzer HR, Verdorfer I, Luetjens CM, Ortmann O, Bornstein SR, Schmitz G. Horm. Metab. Res. 39, 322-35, (2007). View articlePMID: 17533573

3.Control of angiogenesis by AIBP-mediated cholesterol efflux. Fang L, Choi SH, Baek JS, Liu C, Almazan F, Ulrich F, Wiesner P, Taleb A, Deer E, Pattison J, Torres-Vazquez J, Li AC, Miller YI. Nature 498, 118-22, (2013). PMID: 23719382

4.NAXE Mutations Disrupt the Cellular NAD(P)HX Repair System and Cause a Lethal Neurometabolic Disorder of Early Childhood. Kremer LS, Danhauser K, Herebian D, Petkovic Ramadza D, Piekutowska-Abramczuk D, Seibt A, Muller-Felber W, Haack TB, Ploski R, Lohmeier K, Schneider D, Klee D, Rokicki D, Mayatepek E, Strom TM, Meitinger T, Klopstock T, Pronicka E, Mayr JA, Baric I, Distelmaier F, Prokisch H. Am. J. Hum. Genet. 99, 894-902, (2016). PMID: 27616477

Further reading

5. Vitamer levels, stress response, enzyme activity, and gene regulation of Arabidopsis lines mutant in the pyridoxine/pyridoxamine 5'-phosphate oxidase (PDX3) and the pyridoxal kinase (SOS4) genes involved in the vitamin B6 salvage pathway. Gonzalez E, Danehower D, Daub ME. Plant Physiol. 145, 985-96, (2007). View articlePMID: 17873088

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.