PTHR13462

CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL

PANTHER entry
Member databasePANTHER
PANTHER typefamily

Description
Imported from IPR039055

This entry represents the MCU family, whose members include MCU and MCUb from mammals and MCU1-6 from Arabidopsis. MCU is a mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria
[3, 4, 1]
. MCUb negatively regulates the activity of MCU
[2]
.

References
Imported from IPR039055

1.MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival. Mallilankaraman K, Doonan P, Cardenas C, Chandramoorthy HC, Muller M, Miller R, Hoffman NE, Gandhirajan RK, Molgo J, Birnbaum MJ, Rothberg BS, Mak DO, Foskett JK, Madesh M. Cell 151, 630-44, (2012). View articlePMID: 23101630

2.The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit. Raffaello A, De Stefani D, Sabbadin D, Teardo E, Merli G, Picard A, Checchetto V, Moro S, Szabo I, Rizzuto R. EMBO J. 32, 2362-76, (2013). View articlePMID: 23900286

3.A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter. De Stefani D, Raffaello A, Teardo E, Szabo I, Rizzuto R. Nature 476, 336-40, (2011). View articlePMID: 21685888

4.Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. Baughman JM, Perocchi F, Girgis HS, Plovanich M, Belcher-Timme CA, Sancak Y, Bao XR, Strittmatter L, Goldberger O, Bogorad RL, Koteliansky V, Mootha VK. Nature 476, 341-5, (2011). View articlePMID: 21685886

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