PTHR13864

T-CELL ACUTE LYMPHOCYTIC LEUKEMIA/STEM CELL LEUKEMIA-RELATED

PANTHER entry
Member databasePANTHER
PANTHER typefamily

Description
Imported from IPR040238

This entry includes highly related proteins with a Myc-type, basic helix-loop-helix (bHLH) domain, including T-cell acute lymphocytic leukemia proteins 1 and 2 (TAL1 and TAL2), helix-loop-helix proteins 1 and 2 (NHLH1/HEN1 and NHLH2/HEN2), and protein lyl-1 (LYL1). The bHLH domain is required for protein dimerization and DNA binding
[1]
. TAL1 may be a positive regulator of erythroid differentiation
[2]
. The TAL1 and TAL2 genes are altered in T-cell acute lymphoblastic leukemia
[1]
. The NHLH1 and NHLH2 genes are expressed in the developing nervous system, especially cell lines derived from neuroblastoma, PNET, and small cell lung cancer
[3]
, and the proteins may have regulatory functions in the developing nervous system
[4]
. LYL1 has a role in primitive erythropoiesis
[6]
. A chromosomal aberration involving the LYL1 gene may be a cause of a form of T-cell acute lymphoblastic leukemia
[5]
.

References
Imported from IPR040238

1.TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia. Xia Y, Brown L, Yang CY, Tsan JT, Siciliano MJ, Espinosa R 3rd, Le Beau MM, Baer RJ. Proc. Natl. Acad. Sci. U.S.A. 88, 11416-20, (1991). View articlePMID: 1763056

2.The SCL gene product: a positive regulator of erythroid differentiation. Aplan PD, Nakahara K, Orkin SH, Kirsch IR. EMBO J. 11, 4073-81, (1992). PMID: 1396592

3.A comparative structural characterization of the human NSCL-1 and NSCL-2 genes. Two basic helix-loop-helix genes expressed in the developing nervous system. Lipkowitz S, Gobel V, Varterasian ML, Nakahara K, Tchorz K, Kirsch IR. J. Biol. Chem. 267, 21065-71, (1992). PMID: 1328219

4.HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are coexpressed in a human neuroblastoma. Brown L, Espinosa R 3rd, Le Beau MM, Siciliano MJ, Baer R. Proc. Natl. Acad. Sci. U.S.A. 89, 8492-6, (1992). View articlePMID: 1528853

5.lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif. Mellentin JD, Smith SD, Cleary ML. Cell 58, 77-83, (1989). View articlePMID: 2752424

6.A novel role for Lyl1 in primitive erythropoiesis. Chiu SK, Saw J, Huang Y, Sonderegger SE, Wong NC, Powell DR, Beck D, Pimanda JE, Tremblay CS, Curtis DJ. Development 145, (2018). View articlePMID: 30185409

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