PTHR13992

Nuclear receptor corepressor
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameN-CoR_corepressor
AI

Description

AI-generatedUnreviewed
This family of proteins functions as transcriptional corepressors for nuclear receptors. They are involved in chromatin condensation, which restricts access of basal transcription machinery to DNA, thereby repressing gene expression. Members of this family contain conserved CORNR box motifs that are essential for binding to unligated nuclear hormone receptors. Flanking sequences of the CORNR box determine specificity for different nuclear receptors. These proteins are implicated in various biological processes including the regulation of circadian rhythm, lipid metabolism in the liver, and cellular proliferation. They participate in complexes that promote histone deacetylation, contributing to the formation of repressive chromatin structures. Additionally, they play roles in the regulation of B-cell proliferation and survival within germinal centers, and are involved in androgen receptor signaling.
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