This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member database | PANTHER |
PANTHER type | family |
Short name | MHC-II_Gamma/Thyroglobulin AI |
Description
AI-generatedUnreviewed
The protein family includes two distinct groups with different functions. One group, the HLA/H-2 class II histocompatibility antigen gamma chains, plays a pivotal role in the immune system by stabilizing MHC class II alpha/beta heterodimers, facilitating antigen presentation, and interacting with CD44 to enhance T-cell responses. They also act as chaperones for CTSL and have antiviral properties against pathogens like Ebola virus and SARS-CoV-2. The other group, thyroglobulin, is essential for thyroid hormone synthesis, acting as a precursor for iodinated hormones T3 and T4. Thyroglobulin undergoes iodination and coupling of tyrosine residues, followed by proteolysis to release the hormones into the bloodstream. Both groups are critical for their respective physiological processes, with the former involved in immune defense and the latter in metabolic regulation.
Integrated to
External Links
Representative structure
1icf: CRYSTAL STRUCTURE OF MHC CLASS II ASSOCIATED P41 II FRAGMENT IN COMPLEX WITH CATHEPSIN L