PTHR14096

APOLIPOPROTEIN L

PANTHER entry
Member databasePANTHER
PANTHER typefamily

Description
Imported from IPR008405

Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia
[1]
. The various functions of apoL are still not entirely clear. Apolipoprotein L-I has been identified as a trypanolytic agent
[2]
and displays similar phylogenetic distribution to the programmed cell death protein Bcl-2 and BH-3 domain-containing proteins, suggesting a possible role in apoptosis
[3]
.

References
Imported from IPR008405

1.Gene expression analysis in schizophrenia: reproducible up-regulation of several members of the apolipoprotein L family located in a high-susceptibility locus for schizophrenia on chromosome 22. Mimmack ML, Ryan M, Baba H, Navarro-Ruiz J, Iritani S, Faull RL, McKenna PJ, Jones PB, Arai H, Starkey M, Emson PC, Bahn S. Proc. Natl. Acad. Sci. U.S.A. 99, 4680-5, (2002). View articlePMID: 11930015

2.Apolipoprotein L-I is the trypanosome lytic factor of human serum. Vanhamme L, Paturiaux-Hanocq F, Poelvoorde P, Nolan DP, Lins L, Van Den Abbeele J, Pays A, Tebabi P, Van Xong H, Jacquet A, Moguilevsky N, Dieu M, Kane JP, De Baetselier P, Brasseur R, Pays E. Nature 422, 83-7, (2003). View articlePMID: 12621437

3.The function of apolipoproteins L. Vanhollebeke B, Pays E. Cell. Mol. Life Sci. 63, 1937-44, (2006). View articlePMID: 16847577

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