PTHR14224

PRAME domain-containing protein
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short namePRAME_domain
AI

Description

AI-generatedUnreviewed
This family of proteins includes members that are involved in various cellular processes such as the negative regulation of Toll-like receptor-mediated NF-kappa-B signaling, maintenance and self-renewal of pluripotent embryonic stem cells, DNA methylation regulation, spermatogenesis, oogenesis, and ubiquitination of target proteins leading to their degradation. Some family members function as substrate-recognition components of E3 ubiquitin-protein ligase complexes, while others may play roles in chromatin regulation and transcriptional repression, particularly in the context of retinoic acid signaling. The diverse functions suggest that this family has roles in cell differentiation, proliferation, and immune response regulation.
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