PTHR15020

Polyketide-derived toxin biosynthesis oxidoreductase
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short namePolyketide_toxin_oxido
AI

Description

AI-generatedUnreviewed
The avfA family consists of oxidoreductases involved in the biosynthesis of various polyketide-derived toxins and secondary metabolites with diverse biological activities. These enzymes play key roles in the formation of mycotoxins such as dothistromin, sterigmatocystin, and aflatoxins, which are among the most toxic and carcinogenic compounds known. They also participate in the biosynthesis of other compounds like dibenzodioxocinones, pyranonigrins, and xanthones, which have applications ranging from antimicrobial to antioxidative properties. The avfA family members are typically part of larger gene clusters encoding enzymes for specific biosynthetic pathways, and they catalyze various reactions including oxidation, reduction, dehydration, and ring closure, which are critical for the structural diversification and bioactivity of the metabolites produced.
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