PTHR15139

TUBULIN FOLDING COFACTOR C

PANTHER entry
Member databasePANTHER
PANTHER typefamily

Description
Imported from IPR027684

The tubulin heterodimer consists of one alpha- and one beta-tubulin polypeptide. In humans, five tubulin-specific chaperones termed TBCA/B/C/D/E are essential for bring the alpha- and beta-tubulin subunits together into a tightly associated heterodimer. Following the generation of quasi-native beta- and alpha-tubulin polypeptides (via multiple rounds of ATP-dependent interaction with the cytosolic chaperonin), TBCA and TBCB bind to and stabilise newly synthesised beta- and alpha-tubulin, respectively. The exchange of beta-tubulin between TBCA and TBCD, and of alpha-tubulin between TBCB and TBCE, resulting in the formation of TBCD/beta and TBCE/alpha. These two complexes then interact with each other and form a supercomplex (TBCE/alpha/TBCD/beta). Interaction of the supercomplex with TBCC causes the disassembly of the supercomplex and the release of E-site GDP-bound alpha/beta tubulin heterodimer, which becomes polymerization competent following spontaneous exchange with GTP
[2]
.

This entry represents tubulin-specific chaperone C (TBCC, also known as tubulin-folding cofactor C), which is involved in the final step of the tubulin folding pathway
[1, 3]
. In Arabidopsis thaliana, it is required for continuous microtubule cytoskeleton organisation, mitotic division, cytokinesis, and to couple cell cycle progression to cell division in embryos and endosperms
[4, 5]
.

References
Imported from IPR027684

1.Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C. Bartolini F, Bhamidipati A, Thomas S, Schwahn U, Lewis SA, Cowan NJ. J. Biol. Chem. 277, 14629-34, (2002). View articlePMID: 11847227

2.Tubulin-specific chaperones: components of a molecular machine that assembles the α/β heterodimer. Tian G, Cowan NJ. Methods Cell Biol. 115, 155-71, (2013). View articlePMID: 23973072

3.The Arabidopsis PILZ group genes encode tubulin-folding cofactor orthologs required for cell division but not cell growth. Steinborn K, Maulbetsch C, Priester B, Trautmann S, Pacher T, Geiges B, Kuttner F, Lepiniec L, Stierhof YD, Schwarz H, Jurgens G, Mayer U. Genes Dev. 16, 959-71, (2002). View articlePMID: 11959844

4.Mutations in the pilz group genes disrupt the microtubule cytoskeleton and uncouple cell cycle progression from cell division in Arabidopsis embryo and endosperm. Mayer U, Herzog U, Berger F, Inze D, Jurgens G. Eur. J. Cell Biol. 78, 100-8, (1999). PMID: 10099932

5.Functional analysis of the tubulin-folding cofactor C in Arabidopsis thaliana. Kirik V, Mathur J, Grini PE, Klinkhammer I, Adler K, Bechtold N, Herzog M, Bonneville JM, Hulskamp M. Curr. Biol. 12, 1519-23, (2002). View articlePMID: 12225668

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