PTHR15439

RETINOBLASTOMA-BINDING PROTEIN 6

PANTHER entry
Member databasePANTHER
PANTHER typefamily

Description
Imported from IPR033489

RBBP6 interacts with both p53 and pRb and has been implicated in mRNA processing
[3]
. It also acts as a E3 ubiquitin-protein ligase that interacts with YB-1 and ZBTB38, leading to ubiquitination of both proteins
[1, 2]
. It is involved in regulating DNA replication and common fragile site stability
[2]
.

This family also includes the homologues from yeast Mpe1
[4]
and PARAQUAT TOLERANCE3 from Arabidopsis
[5]
.

References
Imported from IPR033489

1.RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1. Chibi M, Meyer M, Skepu A, G Rees DJ, Moolman-Smook JC, Pugh DJ. J. Mol. Biol. 384, 908-16, (2008). View articlePMID: 18851979

2.The RBBP6/ZBTB38/MCM10 axis regulates DNA replication and common fragile site stability. Miotto B, Chibi M, Xie P, Koundrioukoff S, Moolman-Smook H, Pugh D, Debatisse M, He F, Zhang L, Defossez PA. Cell Rep 7, 575-87, (2014). View articlePMID: 24726359

3.RBBP6 isoforms regulate the human polyadenylation machinery and modulate expression of mRNAs with AU-rich 3' UTRs. Di Giammartino DC, Li W, Ogami K, Yashinskie JJ, Hoque M, Tian B, Manley JL. Genes Dev. 28, 2248-60, (2014). View articlePMID: 25319826

4.Efficient mRNA polyadenylation requires a ubiquitin-like domain, a zinc knuckle, and a RING finger domain, all contained in the Mpe1 protein. Lee SD, Moore CL. Mol. Cell. Biol. 34, 3955-67, (2014). View articlePMID: 25135474

5.PARAQUAT TOLERANCE3 Is an E3 Ligase That Switches off Activated Oxidative Response by Targeting Histone-Modifying PROTEIN METHYLTRANSFERASE4b. Luo C, Cai XT, Du J, Zhao TL, Wang PF, Zhao PX, Liu R, Xie Q, Cao XF, Xiang CB. PLoS Genet. 12, e1006332, (2016). View articlePMID: 27676073

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