PTHR15458

PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE

PANTHER entry
Member databasePANTHER
PANTHER typefamily

Description
Imported from IPR024960

This family includes yeast phosphatidyl-N-methylethanolamine N-methyltransferase CHO1/OPI3
[3]
and vertebrates phosphatidylethanolamine N-methyltransferases
[1, 2]
. In yeast, this enzyme catalyzes the second two steps of the methylation pathway of phosphatidylcholine (PC) biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to PC. In vertebrates, it catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to PC.

References
Imported from IPR024960

1.Yeast phosphatidylethanolamine methylation pathway. Cloning and characterization of two distinct methyltransferase genes. Kodaki T, Yamashita S. J. Biol. Chem. 262, 15428-35, (1987). View articlePMID: 2445736

2.Structure, expression profile and alternative processing of the human phosphatidylethanolamine N-methyltransferase (PEMT) gene. Shields DJ, Agellon LB, Vance DE. Biochim. Biophys. Acta 1532, 105-14, (2001). View articlePMID: 11420179

3.The Schizosaccharomyces pombe cho1+ gene encodes a phospholipid methyltransferase. Kanipes MI, Hill JE, Henry SA. Genetics 150, 553-62, (1998). PMID: 9755189

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