PTHR15741

Max-like/E-box-binding transcription factors
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameMax-like/E-box_TFs
AI

Description

AI-generatedUnreviewed
The protein family in question is involved in transcriptional regulation, with members forming sequence-specific DNA-binding complexes that recognize the E box motif 5'-CACGTG-3'. These complexes can act as transcriptional repressors or activators, depending on the context and interacting partners. Family members are implicated in various biological processes including glycolytic gene regulation, fat oxidation, mitochondrial respiration, lifespan maintenance, fertility, body size regulation, autophagy, cell migration, and stress responses. They play roles in modulating longevity in response to multiple signaling pathways and environmental factors, and in the transcriptional regulation of genes encoding extracellular matrix components. Some members are also involved in host-pathogen interactions, influencing the infection by certain pathogens.
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