PTHR16777

PROTEIN ECT2

PANTHER entry
Member databasePANTHER
PANTHER typefamily

Description
Imported from IPR026817

Epithelial Cell Transforming Sequence 2 (Ect2) is a guanine nucleotide exchange factor (GEF) that catalyses the exchange of GDP for GTP. Like other GEFs, Ect2 serves as molecular switches in diverse signaling pathways, including cell polarity, mitotic spindle assembly, cytokinesis, etc
[1, 2, 3]
. Ect2 interacts with several members of the Rho GTPase family including, RhoA, RhoB, RhoC, RhoG, Rac1 and Cdc42
[7, 8, 9, 5, 6]
. Ect2 regulates the formation of the actomyosin contractile ring at mitotic exit through activation of RhoA and functions in metaphase for the process of spindle assembly through activation of Cdc42
[4]
. Ect2 is regulated through a number of mechanisms including phosphorylation, intracellular localization and intra- and inter-molecular interactions
[4]
.

References
Imported from IPR026817

1.Potential roles of the nucleotide exchange factor ECT2 and Cdc42 GTPase in spindle assembly in Xenopus egg cell-free extracts. Tatsumoto T, Sakata H, Dasso M, Miki T. J. Cell. Biochem. 90, 892-900, (2003). View articlePMID: 14624449

2.The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. Joberty G, Petersen C, Gao L, Macara IG. Nat. Cell Biol. 2, 531-9, (2000). View articlePMID: 10934474

3.An ECT2-centralspindlin complex regulates the localization and function of RhoA. Yuce O, Piekny A, Glotzer M. J. Cell Biol. 170, 571-82, (2005). View articlePMID: 16103226

4.The guanine nucleotide exchange factor (GEF) Ect2 is an oncogene in human cancer. Fields AP, Justilien V. Adv. Enzyme Regul. 50, 190-200, (2010). View articlePMID: 19896966

5.Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis. Tatsumoto T, Xie X, Blumenthal R, Okamoto I, Miki T. J. Cell Biol. 147, 921-8, (1999). View articlePMID: 10579713

6.RhoG signals in parallel with Rac1 and Cdc42. Wennerberg K, Ellerbroek SM, Liu RY, Karnoub AE, Burridge K, Der CJ. J. Biol. Chem. 277, 47810-7, (2002). View articlePMID: 12376551

7.Deregulation and mislocalization of the cytokinesis regulator ECT2 activate the Rho signaling pathways leading to malignant transformation. Saito S, Liu XF, Kamijo K, Raziuddin R, Tatsumoto T, Okamoto I, Chen X, Lee CC, Lorenzi MV, Ohara N, Miki T. J. Biol. Chem. 279, 7169-79, (2004). View articlePMID: 14645260

8.Requirement for C-terminal sequences in regulation of Ect2 guanine nucleotide exchange specificity and transformation. Solski PA, Wilder RS, Rossman KL, Sondek J, Cox AD, Campbell SL, Der CJ. J. Biol. Chem. 279, 25226-33, (2004). View articlePMID: 15073184

9.Oncogene ect2 is related to regulators of small GTP-binding proteins. Miki T, Smith CL, Long JE, Eva A, Fleming TP. Nature 362, 462-5, (1993). View articlePMID: 8464478

Further reading

10. Correlation between ECT2 gene expression and methylation change of ECT2 promoter region in pancreatic cancer. Zhang ML, Lu S, Zhou L, Zheng SS. HBPD INT 7, 533-8, (2008). PMID: 18842503

11. Ect2, an ortholog of Drosophila's pebble, negatively regulates neurite outgrowth in neuroblastoma × glioma hybrid NG108-15 cells. Tsuji T, Higashida C, Yoshida Y, Islam MS, Dohmoto M, Koizumi K, Higashida H. Cell. Mol. Neurobiol. 31, 663-8, (2011). View articlePMID: 21350944

12. The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma. Salhia B, Tran NL, Chan A, Wolf A, Nakada M, Rutka F, Ennis M, McDonough WS, Berens ME, Symons M, Rutka JT. Am. J. Pathol. 173, 1828-38, (2008). PMID: 19008376

13. Involvement of epithelial cell transforming sequence-2 oncoantigen in lung and esophageal cancer progression. Hirata D, Yamabuki T, Miki D, Ito T, Tsuchiya E, Fujita M, Hosokawa M, Chayama K, Nakamura Y, Daigo Y. Clin. Cancer Res. 15, 256-66, (2009). View articlePMID: 19118053

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