PTHR18866

Biotin-dependent Carboxylase Complex
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameBiotin_carboxylase_complex
AI

Description

AI-generatedUnreviewed
The protein family is involved in various biotin-dependent carboxylation reactions essential for metabolizing fatty acids, amino acids, and other compounds. Members possess a biotin carboxylation/carboxylase (BC) domain that transiently carboxylates biotin, and a biotinyl-binding/biotin carboxyl carrier (BCC) domain for biotin attachment. Key reactions include the conversion of propionyl-CoA to D-methylmalonyl-CoA, crucial in the catabolism of odd chain fatty acids and branched-chain amino acids, and the transformation of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, vital for leucine catabolism. Some members also participate in the carboxylation of acetyl-CoA to form malonyl-CoA, pyruvate carboxylation to oxaloacetate, and urea hydrolysis. The family's enzymes are involved in mitochondrial and cytoplasmic processes, playing a significant role in cellular energy metabolism and biosynthetic pathways.
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