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Member database | PANTHER |
PANTHER type | family |
Short name | Biotin_carboxylase_complex AI |
Description
AI-generatedUnreviewed
The protein family is involved in various biotin-dependent carboxylation reactions essential for metabolizing fatty acids, amino acids, and other compounds. Members possess a biotin carboxylation/carboxylase (BC) domain that transiently carboxylates biotin, and a biotinyl-binding/biotin carboxyl carrier (BCC) domain for biotin attachment. Key reactions include the conversion of propionyl-CoA to D-methylmalonyl-CoA, crucial in the catabolism of odd chain fatty acids and branched-chain amino acids, and the transformation of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, vital for leucine catabolism. Some members also participate in the carboxylation of acetyl-CoA to form malonyl-CoA, pyruvate carboxylation to oxaloacetate, and urea hydrolysis. The family's enzymes are involved in mitochondrial and cytoplasmic processes, playing a significant role in cellular energy metabolism and biosynthetic pathways.
Integrated to
External Links
Representative structure
6ybq: Engineered glycolyl-CoA carboxylase (quintuple mutant) with bound CoA