Member database | PANTHER |
PANTHER type | family |
Description Imported from IPR018499
Tetraspanins are a distinct family of proteins, containing four transmembrane domains: a small outer loop (EC1), a larger outer loop (EC2), a small inner loop (IL) and short cytoplasmic tails. They contain characteristic structural features, including 4-6 conserved extracellular cysteine residues, and polar residues within transmembrane domains. A fundamental role of tetraspanins appears to be organizing other proteins into a network of multimolecular membrane microdomains, sometimes called the 'tetraspanin web'.
This entry represents tetraspanin proteins. It also recognises a number of peripherins. These are related retinal-specific members of the tetraspanin family which are located at the rims of the photoreceptor disks, where they may act jointly in disk morphogenesis
[1].
References Imported from IPR018499
1.Cloning of the cDNA for a novel photoreceptor membrane protein (rom-1) identifies a disk rim protein family implicated in human retinopathies. Bascom RA, Manara S, Collins L, Molday RS, Kalnins VI, McInnes RR. Neuron 8, 1171-84, (1992). View articlePMID: 1610568