PTHR19961

FIMBRIN/PLASTIN

PANTHER entry
Member databasePANTHER
PANTHER typefamily

Description
Imported from IPR039959

This entry includes fimbrin and plastin from yeasts to humans. They are actin filament-binding proteins that cross-linking actin filaments into tight bundles
[1]
.

Mammlian fimbrin, also known as plastin, has three isoforms: T-plastin (Plastin-3) is expressed in cells from solid tissue, whereas L-plastin (Plastin-2) occurs predominantly in hematopoietic cells. The third isoform, I-plastin (Plastin-1), is specifically expressed in the small intestine, colon and kidney
[1]
.

References
Imported from IPR039959

1.Plastins: versatile modulators of actin organization in (patho)physiological cellular processes. Delanote V, Vandekerckhove J, Gettemans J. Acta Pharmacol. Sin. 26, 769-79, (2005). View articlePMID: 15960882

Further reading

2. Isoform-specific complementation of the yeast sac6 null mutation by human fimbrin. Adams AE, Shen W, Lin CS, Leavitt J, Matsudaira P. Mol. Cell. Biol. 15, 69-75, (1995). View articlePMID: 7799970

3. A yeast actin-binding protein is encoded by SAC6, a gene found by suppression of an actin mutation. Adams AE, Botstein D, Drubin DG. Science 243, 231-3, (1989). View articlePMID: 2643162

4. Suppressor analysis of fimbrin (Sac6p) overexpression in yeast. Sandrock TM, Brower SM, Toenjes KA, Adams AE. Genetics 151, 1287-97, (1999). PMID: 10101157

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