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Member database | PANTHER |
PANTHER type | family |
Short name | Synaptobrevin-like_transport AI |
Description
AI-generatedUnreviewed
This family of proteins is involved in the intracellular transport processes, specifically in the targeting and fusion of transport vesicles with their respective target membranes. Members of this family play a crucial role in various vesicle-mediated transport pathways, including the transport of proteins from the early endosome to the lysosome, the export of chylomicrons from the endoplasmic reticulum to the Golgi apparatus, and the exocytosis of mediators during immune cell degranulation. They are also required for the fusion of late endosomes with lysosomes, lysosomal exocytosis regulated by calcium, and the formation of phagosomes. The presence of a longin domain in some members suggests a role in vacuolar localization and subcellular targeting.
Integrated to
External Links
Representative structure
4b93: Complex of Vamp7 cytoplasmic domain with 2nd ankyrin repeat domain of Varp