PTHR21581

D-alanyl-D-alanine Carboxypeptidase
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameDala-Dala_Carboxypeptidase
AI

Description

AI-generatedUnreviewed
The D-alanyl-D-alanine carboxypeptidase family is involved in bacterial cell wall biosynthesis and remodeling. Members of this family are peptidases that typically remove C-terminal D-alanyl residues from sugar-peptide cell wall precursors, which is a crucial step in the maturation of the cell wall. Some members may also hydrolyze DD-diaminopimelate-alanine bonds in murein sacculi, playing a specialized role in cell wall formation. The family includes proteins that are essential for spore cortex synthesis and maintenance of colony morphology, cell wall permeability, and integrity. Activity of some family members can be regulated by beta-lactam antibiotics, indicating their potential role as targets for antibacterial drugs. The family is characterized by the peptidase S11 family signature and includes proteins with a C-terminal amphiphilic helix targeting them to the periplasmic side of the inner cell membrane.
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