PTHR22599

MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB

PANTHER entry
Member databasePANTHER
PANTHER typefamily

Description
Imported from IPR005301

The MOB kinase activator family includes MOB1, an essential Saccharomyces cerevisiae protein, identified from a two-hybrid screen, that binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Conditional alleles of MOB1 cause a late nuclear division arrest at restrictive temperature
[1]
. This family also includes the MOB-like protein phocein, an intracellular protein that interacts with striatin and may play a role in membrane trafficking
[2]
.

References
Imported from IPR005301

1.MOB1, an essential yeast gene required for completion of mitosis and maintenance of ploidy. Luca FC, Winey M. Mol. Biol. Cell 9, 29-46, (1998). View articlePMID: 9436989

2.Interactions of phocein with nucleoside-diphosphate kinase, Eps15, and Dynamin I. Baillat G, Gaillard S, Castets F, Monneron A. J. Biol. Chem. 277, 18961-6, (2002). View articlePMID: 11872741

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