PTHR22951

CLATHRIN ASSEMBLY PROTEIN

PANTHER entry
Member databasePANTHER
PANTHER typefamily

Description
Imported from IPR045192

Clathrin mediated endocytosis (CME) is a transmembrane cargo and ligand internalisation process that uses a clathrin coat to form vesicles
[3]
. During this process, clathrin needs to be connected to the membrane through adapter proteins, such as the main adapter AP2 (adapter protein complex 2) and AP180. AP180 assembles clathrin faster than any other protein examined in vitro
[2]
. Mammalian AP180 is only detectable in neurons, where it is strongly enriched within pre-synaptic boutons
[1, 4]
. It has been shown that synapses with mutated or disrupted AP180 fail to produce a sufficient number of synaptic vesicles
[5, 4]
.

This entry includes AP180 and related proteins.

References
Imported from IPR045192

1.Turning CALM into excitement: AP180 and CALM in endocytosis and disease. Maritzen T, Koo SJ, Haucke V. Biol. Cell 104, 588-602, (2012). View articlePMID: 22639918

2.The ∼16 kDa C-Terminal Sequence of Clathrin Assembly Protein AP180 Is Essential for Efficient Clathrin Binding. Chan LS, Moshkanbaryans L, Xue J, Graham ME. PLoS ONE 9, e110557, (2014). View articlePMID: 25329427

3.The Biochemical Properties and Functions of CALM and AP180 in Clathrin Mediated Endocytosis. Moshkanbaryans L, Chan LS, Graham ME. Membranes (Basel) 4, 388-413, (2014). View articlePMID: 25090048

4.Synaptic distribution of the endocytic accessory proteins AP180 and CALM. Yao PJ, Petralia RS, Bushlin I, Wang Y, Furukawa K. J. Comp. Neurol. 481, 58-69, (2005). View articlePMID: 15558718

5.A role for the clathrin assembly domain of AP180 in synaptic vesicle endocytosis. Morgan JR, Zhao X, Womack M, Prasad K, Augustine GJ, Lafer EM. J. Neurosci. 19, 10201-12, (1999). PMID: 10575017

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