PTHR23025

Hormone-sensitive lipase
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameHormone-sensitive_lipase
AI

Description

AI-generatedUnreviewed
The Hormone-sensitive lipase family consists of enzymes with broad substrate specificity, catalyzing the hydrolysis of various lipid molecules. Members of this family are involved in the breakdown of triacylglycerols, diacylglycerols, monoacylglycerols, cholesteryl esters, and retinyl esters. They exhibit a preference for hydrolyzing diacylglycerols over triacylglycerols and monoacylglycerols, and typically target fatty acid esters at specific positions on the glycerol backbone. These enzymes play a crucial role in lipid metabolism, including the mobilization of stored triglycerides in adipose tissue and heart to release free fatty acids, and the conversion of cholesteryl esters to free cholesterol in steroidogenic tissues for steroid hormone production. They are also involved in the hydrolysis of bioactive lipids such as endocannabinoids and precursors in the synthesis of platelet-activating factor. Regulation of their activity involves phosphorylation influenced by catecholamines and insulin.
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