PTHR23104

ER-Golgi Transport and Cell Adhesion Regulator
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameER-Golgi_Adhesion_Reg
AI

Description

AI-generatedUnreviewed
The protein family is involved in various cellular processes, including the ER-to-Golgi transport of selected proteins and cell-cell adhesion. Members of the family form a specific cargo receptor complex, known as the MCFD2-LMAN1 complex, which is essential for the secretion of coagulation factors. Additionally, some family members mediate cell-cell adhesion in a calcium-dependent manner and can inhibit cell growth in several cell lines. The presence of EF-hand domains suggests that calcium ions are crucial for the structural folding and function of these proteins.
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