This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member database | PANTHER |
PANTHER type | family |
Short name | ER-Golgi_Adhesion_Reg AI |
Description
AI-generatedUnreviewed
The protein family is involved in various cellular processes, including the ER-to-Golgi transport of selected proteins and cell-cell adhesion. Members of the family form a specific cargo receptor complex, known as the MCFD2-LMAN1 complex, which is essential for the secretion of coagulation factors. Additionally, some family members mediate cell-cell adhesion in a calcium-dependent manner and can inhibit cell growth in several cell lines. The presence of EF-hand domains suggests that calcium ions are crucial for the structural folding and function of these proteins.
Integrated to
External Links
Representative structure
4ygb: Crystal structure of ERGIC-53/MCFD2, monoclinic calcium-free form