This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member database | PANTHER |
PANTHER type | family |
Short name | TRM5/TYW2 AI |
Description
AI-generatedUnreviewed
The TRM5/TYW2 family comprises enzymes involved in the modification of tRNA molecules, specifically at guanosine-37 adjacent to the anticodon. These enzymes methylate the N1 position of guanosine-37, which is crucial for the biosynthesis of wybutosine (yW), a hypermodified guanosine base that plays a key role in accurate decoding during protein synthesis. Some family members also participate in further steps of wybutosine synthesis, such as the transfer of the alpha-amino-alpha-carboxypropyl group to 4-demethylwyosine (imG-14), leading to the formation of wybutosine-86. These modifications are essential for the proper function of tRNAs, particularly for eukaryotic phenylalanine tRNA. The family belongs to the class I-like SAM-binding methyltransferase superfamily and is involved in both cytoplasmic and mitochondrial tRNA methylation processes.
External Links
Representative structure
5hjm: Crystal Structure of Pyrococcus abyssi Trm5a complexed with MTA