PTHR23245

tRNA Guanine-37 Methyltransferase/Wybutosine Synthesis
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameTRM5/TYW2
AI

Description

AI-generatedUnreviewed
The TRM5/TYW2 family comprises enzymes involved in the modification of tRNA molecules, specifically at guanosine-37 adjacent to the anticodon. These enzymes methylate the N1 position of guanosine-37, which is crucial for the biosynthesis of wybutosine (yW), a hypermodified guanosine base that plays a key role in accurate decoding during protein synthesis. Some family members also participate in further steps of wybutosine synthesis, such as the transfer of the alpha-amino-alpha-carboxypropyl group to 4-demethylwyosine (imG-14), leading to the formation of wybutosine-86. These modifications are essential for the proper function of tRNAs, particularly for eukaryotic phenylalanine tRNA. The family belongs to the class I-like SAM-binding methyltransferase superfamily and is involved in both cytoplasmic and mitochondrial tRNA methylation processes.
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