PTHR24044

Notch signaling pathway
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameNotch_signaling
AI

Description

AI-generatedUnreviewed
The Notch signaling pathway family is involved in a wide range of developmental processes and cell fate determinations. Members of this family function as receptors for membrane-bound ligands, such as Jagged and Delta proteins, to regulate differentiation, proliferation, and apoptosis. Activation of Notch receptors leads to the release of the Notch intracellular domain, which forms a transcriptional activator complex and initiates gene expression. This family plays a crucial role in neurogenesis, angiogenesis, somitogenesis, and the development of various tissues including the vascular system, immune system, and muscles. It is also implicated in maintaining stem cell populations and in lateral inhibition, a process ensuring that neighboring cells do not adopt the same differentiation pathway.
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