PTHR24055

Mitogen-activated protein kinase
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameMAP_kinase
AI

Description

AI-generatedUnreviewed
The MAP kinase family is involved in a wide range of cellular processes including cell proliferation, differentiation, migration, transformation, and programmed cell death. Activated by various stimuli such as pro-inflammatory cytokines or physical stress, MAP kinases phosphorylate a broad range of substrates including transcription factors, cytoskeletal elements, and regulators of apoptosis, translation, and other signaling-related molecules. They play key roles in signal transduction pathways like the MAPK/ERK cascade, affecting cell growth, adhesion, survival, and differentiation. Additionally, they are essential for the MAP kinase signal transduction pathway, participating in cascades evoked by extracellular stimuli leading to the activation of transcription factors and phosphorylation of numerous proteins. MAP kinases are also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling, as well as in the fragmentation of the Golgi apparatus during mitosis.
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