PTHR24115

KINESIN-RELATED

PANTHER entry
Member databasePANTHER
PANTHER typefamily

Description
Imported from IPR027640

This entry includes kinesin heavy chain and kinesin-like proteins, which are members of the kinesin superfamily (also known as KIFs). KIFs constitute 15 kinesin families
[3]
. They are important molecular motors that directionally transport various cargos, including membranous organelles, protein complexes and mRNAs
[4]
.

Kinesin
[1, 2, 5]
is a microtubule-associated force-producing protein that play a role in organelle transport. The kinesin motor activity is directed toward the microtubule's plus end. Kinesin is an oligomeric complex composed of two heavy chains and two light chains. The maintenance of the quaternary structure does not require interchain disulphide bonds.

References
Imported from IPR027640

1.Motor proteins 1: kinesins. Bloom GS, Endow SA. 2, 1105-71, (1995). PMID: 8542443

2.Motor proteins of cytoplasmic microtubules. Vallee RB, Shpetner HS. Annu. Rev. Biochem. 59, 909-32, (1990). View articlePMID: 2142876

3.A standardized kinesin nomenclature. Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, Malmberg RL, McIntosh JR, Miki H, Mitchison TJ, Okada Y, Reddy AS, Saxton WM, Schliwa M, Scholey JM, Vale RD, Walczak CE, Wordeman L. J. Cell Biol. 167, 19-22, (2004). View articlePMID: 15479732

4.Kinesin superfamily motor proteins and intracellular transport. Hirokawa N, Noda Y, Tanaka Y, Niwa S. Nat. Rev. Mol. Cell Biol. 10, 682-96, (2009). View articlePMID: 19773780

5.A kinesin medley: biochemical and functional heterogeneity. Brady ST. Trends Cell Biol. 5, 159-64, (1995). View articlePMID: 14732151

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