PTHR24413

Tdpoz family E3 ubiquitin-protein ligase adapters
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameTdpoz_E3_ligase_adapters
AI

Description

AI-generatedUnreviewed
The Tdpoz family proteins function as substrate-specific adapters in cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes, mediating ubiquitination and often proteasomal degradation of target proteins. They contain BTB (POZ) domains for dimerization and interaction with CUL3, and MATH domains for substrate interaction. Some family members regulate transcriptional activation by promoting degradation of specific transcription factors. Others are involved in the regulation of bromodomain and extra-terminal motif (BET) proteins' stability. Variations in complex composition, such as homodimeric or heterodimeric formations, affect the ubiquitin ligase activity.
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