This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member database | PANTHER |
PANTHER type | family |
Short name | Tdpoz_E3_ligase_adapters AI |
Description
AI-generatedUnreviewed
The Tdpoz family proteins function as substrate-specific adapters in cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes, mediating ubiquitination and often proteasomal degradation of target proteins. They contain BTB (POZ) domains for dimerization and interaction with CUL3, and MATH domains for substrate interaction. Some family members regulate transcriptional activation by promoting degradation of specific transcription factors. Others are involved in the regulation of bromodomain and extra-terminal motif (BET) proteins' stability. Variations in complex composition, such as homodimeric or heterodimeric formations, affect the ubiquitin ligase activity.
External Links
Representative structure
7d3d: Crystal structure of SPOP bound with a peptide