PTHR30050

Bacterial chromosomal replication initiator protein DnaA
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameDnaA
AI

Description

AI-generatedUnreviewed
The DnaA family plays a crucial role in the initiation and regulation of chromosomal replication across various bacterial species. Members of this family are responsible for binding to the origin of replication, recognizing a specific 9 bp consensus sequence known as the DnaA box. This interaction is critical for the formation of the DNA replication initiation complex, ensuring that DNA replication occurs precisely once per cell cycle. DnaA proteins have an affinity for ATP and acidic phospholipids, which influences their activity in the replication process. Additionally, some family members, such as the Hda subfamily, are involved in the regulatory inhibition of DnaA, a process called RIDA, which prevents reinitiation of replication by stimulating the hydrolysis of ATP-DnaA to ADP-DnaA, thus maintaining the fidelity of DNA replication.
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