PTHR30175

Phosphotransferase System Sugar-Specific Components
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short namePTS_Sugar-Specific_Components
AI

Description

AI-generatedUnreviewed
The Phosphoenolpyruvate-dependent Sugar Phosphotransferase System (PTS) is a major carbohydrate active transport system that catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The PTS is involved in the transport of various sugars including beta-glucosides, sucrose, trehalose, N-acetylmuramic acid, and MurNAc-GlcNAc. It consists of multiple domains: EIIC forms the translocation channel with a substrate-binding site; EIIB is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the sugar, and transfers the phosphoryl group to the sugar substrate; EIIA is phosphorylated by phospho-HPr on a histidyl residue and transfers the phosphoryl group to EIIB. The system plays a key role in the uptake and phosphorylation of sugars, facilitating their utilization as carbon and energy sources, and is involved in the regulation of various cellular processes.
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