PTHR30390

SIS family GmhA and DiaA subfamilies
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameSIS_GmhA/DiaA_subfam
AI

Description

AI-generatedUnreviewed
The SIS family GmhA subfamily proteins are primarily involved in the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate, a reaction that is part of the biosynthetic pathway for ADP-L-glycero-D-manno-heptose. This compound is a precursor for the heptose moiety of lipopolysaccharides in Gram-negative bacteria, which are essential components of the outer membrane. The activity of these enzymes is crucial for the proper functioning of bacterial cell walls and for the virulence of pathogenic bacteria. The DiaA subfamily members within the SIS family are involved in the initiation of chromosomal replication by interacting with the DnaA initiator protein, which is essential for the timely and accurate duplication of the bacterial genome. The UPF0309 family proteins, however, are uncharacterized within this context and their function remains to be elucidated.
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