This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member database | PANTHER |
PANTHER type | family |
Short name | HpcH_HpaI_aldolase AI |
Description
AI-generatedUnreviewed
The HpcH/HpaI aldolase family is involved in various metabolic pathways, including the ethylmalonyl-CoA pathway for acetate assimilation, the 3-hydroxypropionate cycle for autotrophic carbon dioxide fixation, the glyoxylate assimilation cycle, and fatty acid biosynthesis. Members of this family catalyze reversible condensation reactions involving glyoxylate with acetyl-CoA or propionyl-CoA, as well as cleavage reactions of (S)-malyl-CoA, beta-methylmalyl-CoA, and (S)-citramalyl-CoA. Some proteins also exhibit thioesterase activity, hydrolyzing (3S)-malyl-CoA to (3S)-malate and free CoA. Additionally, citrate lyase beta subunit proteins within this family function as citryl-ACP lyases. The enzymes are regulated by various factors, including divalent cations and EDTA.
External Links
Representative structure
1sgj: Crystal structure of citrate lyase beta subunit