PTHR33360

Transposase 17
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameTransposase_17
AI

Description

AI-generatedUnreviewed
The Transposase 17 family comprises enzymes responsible for the mobility of insertion sequence (IS) elements such as ISDra2 and IS200. Members of this family are necessary for the excision of the IS element from the donor DNA and its reinsertion into a target site, thereby increasing the copy number of the IS element. The transposition process typically involves a 'peel and paste' mechanism or a two-step strand transfer that results in the circularization of the excised IS element followed by its integration into the DNA target. The family is characterized by a catalytic domain containing a highly mobile helix with a critical tyrosine residue. Transposition is regulated by various factors, including other proteins such as TnpB, which can inhibit both excision and insertion steps.
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