This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member database | PANTHER |
PANTHER type | family |
Short name | Zinc_Metalloprotease_M4 AI |
Description
AI-generatedUnreviewed
The Peptidase M4 family comprises extracellular zinc metalloproteases involved in a variety of biological processes, including pathogenesis, immune evasion, and protein activation. Members of this family have been implicated in the degradation of various substrates such as gastric mucus, elastin, collagen, and casein, which may contribute to ulcer formation, bacterial virulence, and tissue colonization. Some family members are known to cleave and activate other proteins, such as transglutaminase and cholera enterotoxin, playing roles in bacterial development and infection. The proteolytic activity of these enzymes is typically regulated by metal chelators, indicating their dependence on metal ions for function.
Integrated to
External Links
Representative structure
5a3y: SAD structure of Thermolysin obtained by multi crystal data collection