PTHR34185

DNA integrity scanning protein DisA
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameDisA
AI

Description

AI-generatedUnreviewed
The DisA family proteins are involved in a DNA-damage checkpoint mechanism active prior to asymmetric division during sporulation. They form globular foci that rapidly scan chromosomes for lesions, pausing at damaged sites to trigger a temporary block in sporulation initiation. Additionally, they possess diadenylate cyclase activity, catalyzing the formation of cyclic di-AMP (c-di-AMP) from ATP. c-di-AMP acts as a signaling molecule linking DNA integrity with sporulation progression. An increase in c-di-AMP levels serves as a positive signal for sporulation to proceed; however, synthesis halts upon DNA damage detection. Some family members are regulated by interactions with RadA or nucleic acid structures, and their activity is essential for various cellular processes including growth, DNA repair, and cell wall homeostasis.
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